Social dominance in male vasopressin 1b receptor knockout mice
- 31 July 2010
- journal article
- Published by Elsevier BV in Hormones and Behavior
- Vol. 58 (2), 257-263
- https://doi.org/10.1016/j.yhbeh.2010.03.008
Abstract
We have previously reported that mice with a targeted disruption of their vasopressin 1b receptor gene, Avpr1b, have mild impairments in social recognition and reduced aggression. The reductions in aggression are limited to social forms of aggression, i.e., maternal and inter-male aggression, while predatory aggression remains unaffected. To further clarify the role of the Avpr1b in the regulation of social behavior we first examined anxiety-like and depression-like behaviors in Avpr1b knockout (Avpr1b −/−) mice. We then went on to test the ability of Avpr1b −/− mice to form dominance hierarchies. No major differences were found between Avpr1b −/− and wildtype mice in anxiety-like behaviors, as measured using an elevated plus maze and an open field test, or depression-like behaviors, as measured using a forced swim test. In the social dominance study we found that Avpr1b −/− mice are able to form dominance hierarchies, though in early hierarchy formation dominant Avpr1b −/− mice display significantly more mounting behavior on Day 1 of testing compared to wildtype controls. Further, non-socially dominant Avpr1b −/− mice spend less time engaged in attack behavior than wildtype controls. These findings suggest that while Avpr1b −/− mice may be able to form dominance hierarchies they appear to employ alternate strategies.Keywords
This publication has 40 references indexed in Scilit:
- Persistence of reduced aggression in vasopressin 1b receptor knockout mice on a more “wild” backgroundPhysiology & Behavior, 2009
- A Conditional Knockout Mouse Line of the Oxytocin ReceptorEndocrinology, 2008
- Vasopressin: Behavioral roles of an “original” neuropeptideProgress in Neurobiology, 2007
- The Hypothalamic-Pituitary-Adrenal Axis Response to Stress in Mice Lacking Functional Vasopressin V1b ReceptorsEndocrinology, 2007
- The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomyNeuroscience, 2006
- Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in miceGenes, Brain and Behavior, 2006
- Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination taskHormones and Behavior, 2004
- Discrimination of social odors and their locations: role of lateral entorhinal areaPhysiology & Behavior, 2004
- Differential Lateral Septal Vasopressin in Wild-type Rats: Correlation with AggressionHormones and Behavior, 1997
- Molecular Cloning and Characterization of Rat V1B Vasopressin Receptor: Evidence for Its Expression in Extrapituitary TissuesBiochemical and Biophysical Research Communications, 1995