Effects of N‐acetylcysteine on glutathione oxidation and fatigue during handgrip exercise
- 7 October 2005
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 32 (5), 633-638
- https://doi.org/10.1002/mus.20385
Abstract
Fatigue of hand and forearm muscle groups can limit task performance by astronauts wearing space suits. Countermeasures to delay fatigue would therefore be useful to the space program. N-acetylcysteine (NAC) has been shown to inhibit fatigue during other tasks so we tested its effects during handgrip exercise. Volunteers practiced isometric handgrip maneuvers until performance was reproducible over three successive sessions (baseline). Performance then was retested after ingesting NAC (150 mg.kg−1) or saline. Drug administration increased NAC and cysteine blood levels (P < 0.001). Performance of sustained maximal efforts was unaffected. During repetitive submaximal efforts, NAC delayed fatigue (130% baseline) and inhibited glutathione oxidation. Saline did not alter glutathione status or performance of sustained maneuvers; repetitive task performance was increased by 15% (P < 0.05), a placebo effect. These data indicate that NAC supports glutathione homeostasis in exercising humans and may delay muscle fatigue during repetitive handgrip exercise. Our findings support oxidative stress as a causal factor in human muscle fatigue and argue for larger translational studies to define NAC effects on human performance. Muscle Nerve, 2005Keywords
This publication has 35 references indexed in Scilit:
- Malleability of human skeletal muscle Na+-K+-ATPase pump with short-term trainingJournal of Applied Physiology, 2004
- Does Oxidative Stress Alter Quadriceps Endurance in Chronic Obstructive Pulmonary Disease?American Journal of Respiratory and Critical Care Medicine, 2004
- Oxidants and Skeletal Muscle Function: Physiologic and Pathophysiologic ImplicationsProceedings of the Society for Experimental Biology and Medicine, 1999
- Effect of supplementation with a cysteine donor on muscular performanceJournal of Applied Physiology, 1999
- Increased Superoxide Production during Fatigue in the Perfused Rat DiaphragmAmerican Journal of Respiratory and Critical Care Medicine, 1997
- Detection of free radicals by electron spin resonance in rat diaphragm after resistive loadingJournal of Applied Physiology, 1994
- Use of N-acetylcysteine in clinical toxicologyAmerican Journal Of Medicine, 1991
- Bioavailability of suckable tablets of oral N-acetylcysteine in manEuropean Journal of Clinical Pharmacology, 1989
- The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acidFree Radical Biology & Medicine, 1989
- Pharmacokinetics of N-acetylcysteine in manEuropean Journal of Clinical Pharmacology, 1986