Rates of cerebral atrophy in autopsy‐confirmed progressive supranuclear palsy
- 22 December 2005
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 59 (1), 200-203
- https://doi.org/10.1002/ana.20707
Abstract
Objective To determine the rates of cerebral atrophy and ventricular expansion in six patients with autopsy confirmed progressive supranuclear palsy (PSP) and multiple antemortem volumetric head MRI scans. Methods This study uses the boundary shift integral to determine rates of cerebral atrophy and ventricular expansion in six patients with pathologically confirmed PSP compared with six age‐ and sex‐matched control subjects. Results: Patients with PSP had a rate of cerebral atrophy and ventricular expansion of 1.3 and 7.0% per year compared with 0.4 and 1.8% in control subjects. Interpretation These rates provide a benchmark that can be used to monitor future treatment response in PSP. Ann Neurol 2006Keywords
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