Upregulating of Fas, integrin β4 and P53 and depressing of PC‐PLC activity and ROS level in VEC apoptosis by safrole oxide
Open Access
- 6 October 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (25), 5809-5813
- https://doi.org/10.1016/j.febslet.2005.09.051
Abstract
Previously, we found that safrole oxide could trigger vascular endothelial cell (VEC) apoptosis. In this study, to investigate its mechanism to induce apoptosis in VECs, the activities of nitric oxide synthetase and phosphatidylcholine specific phospholipase C, the level of reactive oxygen species and the expressions of Fas, integrin β4 and P53 were analyzed. The data showed that safrole oxide induced apoptosis by increasing the expressions of Fas, integrin β4 and P53, and depressing the activity of Ca2+‐independent phosphatidylcholine‐specific phospholipase C and intracellular reactive oxygen species levels in VECs.Keywords
This publication has 23 references indexed in Scilit:
- Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cellsBioorganic & Medicinal Chemistry, 2005
- Homocysteine Enhances Endothelial Apoptosis via Upregulation of Fas-Mediated PathwaysHypertension, 2004
- Angiopoietin-1 Inhibits Doxorubicin-Induced Human Umbilical Vein Endothelial Cell Death by Modulating Fas Expression and via the PI3K/Akt PathwayEndothelium, 2004
- Endothelial expression of the α6β4 integrin is negatively regulated during angiogenesisJournal of Cell Science, 2003
- Sphingosine 1-Phosphate Protects Human Umbilical Vein Endothelial Cells from Serum-deprived Apoptosis by Nitric Oxide ProductionJournal of Biological Chemistry, 2001
- Integrin β4 Is Involved in Apoptotic Signal Transduction in Endothelial CellsBiochemical and Biophysical Research Communications, 1997
- Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatographyBiochemistry, 1984
- The side-chain epoxidation and hydroxylation of the hepatocarcinogens safrole and estragole and some related compounds by rat and mouse liver microsomesBiochimica et Biophysica Acta (BBA) - General Subjects, 1981
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIAJCI Insight, 1973
- The Synthesis of Some Tertiary Amino Alcohols Related to ChelidonineJournal of the American Chemical Society, 1946