Management of Prematurity-Associated Wheeze and Its Association with Atopy
Open Access
- 20 May 2016
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 11 (5), e0155695
- https://doi.org/10.1371/journal.pone.0155695
Abstract
Although preterm birth is associated with respiratory morbidity in childhood, the role of family history of atopy and whether appropriate treatment has been instituted is unclear. Thus we assessed (i) the prevalence of respiratory symptoms, particularly wheezing, in childhood; (ii) evaluated the role of family history of atopy and mode of delivery, and (iii) documented the drug usage, all in preterm-born children compared to term-born control children. We conducted a cross-sectional population-based questionnaire study of 1–10 year-old preterm-born children (n = 13,361) and matched term-born controls (13,361). Data (n = 7,149) was analysed by gestational groups (24–32 weeks, 33–34 weeks, 35–36 weeks and 37–43 weeks) and by age, <5 years old or ≥ 5 years. Preterm born children aged <5 years (n = 2,111, term n = 1,402) had higher rates of wheeze-ever [odds ratio: 2.7 (95% confidence intervals 2.2, 3.3); 1.8 (1.5, 2.2); 1.5 (1.3, 1.8) respectively for the 24–32 weeks, 33–34 weeks, 35–36 weeks groups compared to term]. Similarly for the ≥5 year age group (n = 2,083, term n = 1,456) wheezing increased with increasing prematurity [odds ratios 3.3 (2.7, 4.1), 1.8 (1.5, 2.3) and 1.6 (1.3, 1.9) for the three preterm groups compared to term]. At both age groups, inhaler usage was greater in the lowest preterm group but prematurity-associated wheeze was independent of a family history of atopy. Increasing prematurity was associated with increased respiratory symptoms, which were independent of a family history of atopy. Use of bronchodilators was also increased in the preterm groups but its efficacy needs careful evaluation.Keywords
Funding Information
- Medical Research Council (MR/M022552/1)
- Mason Medical Research Foundation
This publication has 44 references indexed in Scilit:
- Respiratory Syncytial Virus and Recurrent WheezeThe New England Journal of Medicine, 2013
- Moderately Preterm Children Have More Respiratory Problems during Their First 5 Years of Life Than Children Born Full TermAmerican Journal of Respiratory and Critical Care Medicine, 2013
- Why Do Former Preterm Infants Wheeze?The Journal of Pediatrics, 2013
- Assessing the Liverpool Respiratory Symptom Questionnaire in children with cystic fibrosisEuropean Respiratory Journal, 2011
- The new bronchopulmonary dysplasiaCurrent Opinion in Pediatrics, 2011
- Lung Function and Respiratory Symptoms at 11 Years in Children Born Extremely PretermAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Spirometric Lung Function in School-Age ChildrenAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Validity of Parental Reporting of Recent Episodes of Acute Otitis Media: A Slone Center Office-based Research (SCOR) Network StudyThe Journal of the American Board of Family Medicine, 2007
- International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methodsEuropean Respiratory Journal, 1995
- Increased airway responsiveness in children of low birth weight at school age: effect of topical corticosteroids.Archives of Disease in Childhood, 1993