Faculty Opinions recommendation of High glucose instigates tubulointerstitial injury by stimulating hetero-dimerization of adiponectin and angiotensin II receptors.
This article highlights the importance of receptor-receptor physical interaction in the pathophysiology of the kidney. Specifically, heterodimerization of deleterious angiotensin AT1R with protective AT2R is negatively impacted by high glucose and these receptors make new dimers with adiponectin receptors, instigating tubulo-interstitial injury.