Assessment of Cardiac Autonomic Modulation during Adolescent Obesity
- 1 April 2003
- journal article
- Published by Wiley in Obesity Research
- Vol. 11 (4), 541-548
- https://doi.org/10.1038/oby.2003.76
Abstract
To investigate the cardiovascular autonomic function in pediatric obesity of different duration by using standard time domain, spectral heart rate variability (HRV), and nonlinear methods.Fifty obese children (13.9 +/- 1.7 years) were compared with 12 lean subjects (12.9 +/- 1.6 years). Obese children were classified as recent obese (ROB) (7 years). In all participants, we performed blood pressure (BP) measurements, laboratory tests, and 24-hour electrocardiogram/ambulatory BP monitoring. The spectral power was quantified in total power, very low-frequency (LF) power, high-frequency (HF) power, and LF to HF ratio. Total, long-term, and short-term time domain HRV were calculated. Poincaré plot and quadrant methods were used as nonlinear techniques.All obese groups had higher casual and ambulatory BP and higher glucose, homeostasis model assessment, and triglyceride levels. All parameters reflecting parasympathetic tone (HF band, root mean square successive difference, proportion of successive normal-to-normal intervals, and scatterplot width) were significantly and persistently reduced in all obese groups in comparison with lean controls. LF normalized units, LF/HF, and cardiac acceleration (reflecting sympathetic activation) were significantly increased in the ROB group. In IOB and OB groups, LF, but not nonlinear, measures were similar to lean controls, suggesting biphasic behavior of sympathetic tone, whereas nonlinear analysis showed a decreasing trend with the duration of obesity. Long-term HRV measures were significantly reduced in ROB and IOB.Autonomic nervous system changes in adolescent obesity seem to be related to its duration. Nonlinear methods of scatterplot and quadrant analysis permit assessment of autonomic balance, despite measuring different aspects of HRV.Keywords
This publication has 34 references indexed in Scilit:
- Obesity Hypertension in ChildrenHypertension, 2002
- Weight Gain–Induced Blood Pressure ElevationHypertension, 2000
- Nocturnal Blood Pressure Fall on Ambulatory Monitoring in a Large International DatabaseHypertension, 1997
- Effects of bisoprolol on heart rate variability in heart failureThe American Journal of Cardiology, 1996
- Obesity, the sympathetic nervous system, and essential hypertension.Hypertension, 1992
- Hyperinsulinemia: possible role in obesity-induced hypertension.Hypertension, 1992
- Body Fat and the Activity of the Autonomic Nervous SystemThe New England Journal of Medicine, 1988
- Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.Circulation, 1978
- Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.Circulation, 1977
- The Mean Square Successive DifferenceThe Annals of Mathematical Statistics, 1941