Pertussis toxin inhibits chemotactic factor‐induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils
- 22 April 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 183 (2), 317-320
- https://doi.org/10.1016/0014-5793(85)80801-2
Abstract
Pertussis toxin suppressed [32P]polyphosphoinositide breakdown and lysosomal enzyme secretion induced by fMet-Leu-Phe in rabbit neutrophils. Likewise, fMet-Leu-Phe- or leukotriene B4-evoked (3H]inositol trisphosphate accumulation was inhibited by the toxin. These findings, taken together with evidence that pertussis toxin specifically causes inactivation of the guanine nucleotide binding protein (Ni), suggests that guanine nucleotide binding proteins may mediate coupling between calcium-mobilising receptors and phospholipase C-mediated reactions in rabbit neutrophils.Keywords
This publication has 12 references indexed in Scilit:
- Inhibition of receptor-mediated release of arachidonic acid by pertussis toxinCell, 1984
- ADP-ribosylation of the specific membrane protein by islet-activating protein, pertussis toxin, associated with inhibition of a chemotactic peptide-induced arachidonate release in neutrophils. A possible role of the toxin substrate in Ca2+-mobilizing biosignaling.Journal of Biological Chemistry, 1984
- Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: Possible role of the “G proteins” in calcium mobilizationBiochemical and Biophysical Research Communications, 1984
- Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)FEBS Letters, 1984
- Leukotriene B4 mobilizes calcium without the breakdown of polyphosphoinositides and the production of phosphatidic acid in rabbit neutrophils.Proceedings of the National Academy of Sciences of the United States of America, 1984
- G proteins and dual control of adenylate cyclaseCell, 1984
- Coupling of polyphosphoinositide breakdown with calcium efflux in formyl‐methionyl‐leucyl‐phenylalanine‐stimulated rabbit neutrophilsFEBS Letters, 1983
- Chemotactic factor causes rapid decreases in phosphatidylinositol,4,5-bisphosphate and phosphatidylinositol 4-monophosphate in rabbit neutrophilsBiochemical and Biophysical Research Communications, 1983
- Receptor-mediated net breakdown of phosphatidylinositol 4,5-bisphosphate in parotid acinar cellsBiochemical Journal, 1982