Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases
Open Access
- 1 January 2013
- journal article
- research article
- Published by Medknow in Journal of Indian Society of Periodontology
- Vol. 17 (1), 21-4
- https://doi.org/10.4103/0972-124x.107469
Abstract
Background: Treatment of periodontal diseases by nonsurgical debridement has been considered as a gold standard procedure. Various other treatment modalities have been tried and tested to treat periodontal diseases. The aim of this study was to investigate the effect of antioxidant therapy on the progression of periodontal disease as monotherapy and/or as an adjunct to nonsurgical debridement. Materials and Methods: 70 subjects were divided into three groups, i.e. clinically healthy, gingivitis and periodontitis group on the basis of Community Periodontal Index of Treatment Needs score. Gingivitis and periodontitis groups were further subdivided into three subgroups. At the baseline, periodontal attachment loss was recorded and scaling and root planing was performed in two subgroups. 6 mg antioxidant was administered in three divided doses for 2 weeks. Saliva samples were collected at baseline, 15 th day, 30 th day and 45 th day for evaluation of uric acid levels. Results: Uric acid levels were significantly low in patients with more periodontal attachment loss as compared to clinically healthy and gingivitis groups. As the treatment was initiated, significant increase in uric acid levels was observed. Conclusion: Rise in salivary antioxidant levels was observed on the administration of antioxidant therapy. Hence, antioxidant therapy can be used as an adjunct to the nonsurgical periodontal therapy.Keywords
This publication has 8 references indexed in Scilit:
- The role of reactive oxygen and antioxidant species in periodontal tissue destructionPeriodontology 2000, 2007
- Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial.2007
- Decrease in the total antioxidant activity of saliva in patients with periodontal diseasesClinical Oral Investigations, 2003
- Tomato lycopene and its role in human health and chronic diseases.2000
- The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12‐month resultsJournal of Clinical Periodontology, 2000
- Role of free radicals and antioxidants in the pathogenesis of the inflammatory periodontal diseasesMolecular Pathology, 1996
- Microbial etiological agents of destructive periodontal diseasesPeriodontology 2000, 1994
- Antioxidant Activity of Saliva and Periodontal DiseaseFree Radical Research, 1994