Cancer after Thyroidectomy: A Multi-Institutional Experience with 1,523 Patients
- 11 February 2013
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American College of Surgeons
- Vol. 216 (4), 571-577
- https://doi.org/10.1016/j.jamcollsurg.2012.12.022
Abstract
Background The incidence of thyroid cancer in patients treated operatively for thyroid disease has been historically low (t-tests, and multivariable logistic regression were used. Results Overall, 238 (15.6%) cancers were recorded: Graves' disease (6.1%), nodular goiter (17.5%), and toxic nodular goiter (18.3%). Cancer rates were significantly different among these groups (p < 0.01) and significantly higher in nodular goiter and toxic nodular goiter vs Graves' disease (p < 0.01); no significant differences in cancer rates were noted among institutions. Overall, 275 patients had thyroiditis (18%). There was a significant association with younger age, male sex, nodular thyroids, and cancer (p < 0.05). Presence of thyroiditis or performance of preoperative fine-needle aspiration was not associated with cancer. Mean cancer size was 1.1 cm (46% >0.5 cm; 39% >1 cm). Most patients underwent total thyroidectomy (80%). Conclusions These data confirm higher than expected incidental thyroid cancer rates (15.6%) in the largest multi-institutional surgical series to date. Nodular thyroids, males, and young patients were more likely to harbor incidental carcinoma. These data support consideration of initial total thyroidectomy as the preferred approach for patients referred to the surgeon with bilateral nodular disease.Keywords
This publication has 20 references indexed in Scilit:
- Thyroid Cancer in Patients with HyperthyroidismHormone and Metabolic Research, 2012
- Are There Predictors of Malignancy in Patients with Multinodular Goiter?1Journal of Surgical Research, 2011
- Minimally invasive video-assisted thyroidectomy: an analysis of results and a revision of indicationsSurgical Endoscopy, 2011
- Incidental Papillary Microcarcinoma of the Thyroid—Further Evidence of a Very Low Malignant Potential: A Retrospective Clinicopathological Study With Up to 30 Years of Follow-UpAnnals of Surgical Oncology, 2011
- Incidental papillary carcinoma in patients treated surgically for benign thyroid diseasesSurgery, 2009
- Rising Thyroid Cancer Incidence in the United States by Demographic and Tumor Characteristics, 1980-2005Cancer Epidemiology, Biomarkers & Prevention, 2009
- Is Hashimoto's Thyroiditis a Risk Factor for Papillary Thyroid Cancer?Journal of Surgical Research, 2007
- Increasing Incidence of Thyroid Cancer in the United States, 1973-2002JAMA, 2006
- INCIDENTAL THYROID CARCINOMA IN A LARGE SERIES OF CONSECUTIVE PATIENTS OPERATED ON FOR BENIGN THYROID DISEASEAnz Journal of Surgery, 2006
- Multicentre study of thyroid nodules in patients with Graves' diseaseBritish Journal of Surgery, 2000