Genetic Susceptibility to Goldthioglucose-Induced Obesity in Mice.

Abstract

Five inbred strains of mice (C , C58, RIII, DBA/2 and BALB/c) and five F1 hybrid combinations were studied with respect to the effects of single injections of various concentrations (0.1 to 1.5 mg/gm body weight) of goldthioglucose (GTG) on body weight gain and lethal toxicity. The 60 day post-injection body weight gain and mortality (2-3 days post-injection) were dependent on the strain of mice and amount injected C58 mice appear to be most "susceptible" to GTG in terms of weight gain and toxicity as compared to the more "resistant" BALB/C, RIII, and DBA/2 strains. CBA mice fell within these two extremes. In genera], there was a greater increase in weight gain when larger doses of GTG were administered. The CBA strain of mice were unique in that they showed a uniform response with respect to weight gain and mortality as compared to the other strains. The F1 hybrid mice showed a weight gain response comparable to that of the CBA strain irrespective of whether the other parental strain was "susceptible" or "resistant".