Complete Sequence of the cap Locus of Haemophilus influenzae Serotype b and Nonencapsulated b Capsule-Negative Variants
- 1 June 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (6), 3639-44
- https://doi.org/10.1128/iai.71.6.3639-3644.2003
Abstract
The complete capsule ( cap ) loci from three Haemophilus influenzae strains, one serotype b (Hib) and two nonencapsulated b capsule-negative variants, were sequenced. Two new open reading frames, hcsA and hcsB , were identified in region III and thought to be involved in postpolymerization modification of the capsule. The location of the cap locus in the Haemophilus influenzae chromosome was identified within section 97 of the Rd genome (chromosomal coordinates 1074542 to 1086327) and found to be the same for the Hib and two Hib − strains as well as some other encapsulated division I H. influenzae strains.Keywords
This publication has 34 references indexed in Scilit:
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- The elucidation of novel capsular genotypes of Haemophilus influenzae type b with the polymerase chain reactionJournal of Medical Microbiology, 1995
- INVASTIVE HAEMOPHILUS INFLUENZAE f DISEASEThe Pediatric Infectious Disease Journal, 1995
- Natural Genetic Transfer of a Putative Virulence-Enhancing Mutation to Haemophilus influenzae Type aThe Journal of Infectious Diseases, 1994
- An Ancestral Mutation Enhancing the Fitness and Increasing the Virulence of Haemophilus influenzae Type bThe Journal of Infectious Diseases, 1993
- The Haemophilus influenzae capsulation gene cluster: a compound transposonMolecular Microbiology, 1991
- The bex locus in encapsulated Haemophilus influenzae: a chromosomal region involved in capsule polysaccharide exportMolecular Microbiology, 1990
- Basic local alignment search toolJournal of Molecular Biology, 1990
- Pilus- and Non-Pilus-Mediated Interactions of Haemophilus infiuenzae Type b with Human Erythrocytes and Human Nasopharyngeal MucosaThe Journal of Infectious Diseases, 1990
- Polysaccharide-protein conjugate vaccines for the prevention of Haemophilus influenzae type b diseaseThe Journal of Pediatrics, 1988