Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features
Top Cited Papers
Open Access
- 6 July 2015
- journal article
- review article
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 12 (7), 7519-7540
- https://doi.org/10.3390/ijerph120707519
Abstract
Manganese (Mn) is an essential trace element necessary for physiological processes that support development, growth and neuronal function. Secondary to elevated exposure or decreased excretion, Mn accumulates in the basal ganglia region of the brain and may cause a parkinsonian-like syndrome, referred to as manganism. The present review discusses the advances made in understanding the essentiality and neurotoxicity of Mn. We review occupational Mn-induced parkinsonism and the dynamic modes of Mn transport in biological systems, as well as the detection and pharmacokinetic modeling of Mn trafficking. In addition, we review some of the shared similarities, pathologic and clinical distinctions between Mn-induced parkinsonism and Parkinson’s disease. Where possible, we review the influence of Mn toxicity on dopamine, gamma aminobutyric acid (GABA), and glutamate neurotransmitter levels and function. We conclude with a survey of the preventive and treatment strategies for manganism and idiopathic Parkinson’s disease (PD).Keywords
This publication has 175 references indexed in Scilit:
- Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10, a Manganese Transporter in ManAmerican Journal of Human Genetics, 2012
- Mutations in SLC30A10 Cause Parkinsonism and Dystonia with Hypermanganesemia, Polycythemia, and Chronic Liver DiseaseAmerican Journal of Human Genetics, 2012
- Role of manganese in neurodegenerative diseasesJournal of Trace Elements in Medicine and Biology, 2011
- Cellular fura‐2 Manganese Extraction Assay (CFMEA)Current Protocols in Toxicology, 2011
- Vesicular distribution of Secretory Pathway Ca2+-ATPase isoform 1 and a role in manganese detoxification in liver-derived polarized cellsBioMetals, 2010
- Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brainNeuroToxicology, 2008
- Manganese transport in eukaryotes: The role of DMT1NeuroToxicology, 2008
- Proposed cycles for functional glutamate trafficking in synaptic neurotransmissionNeurochemistry International, 2008
- Direct effects of manganese compounds on dopamine and its metabolite Dopac: An in vitro studyEnvironmental Toxicology and Pharmacology, 2007
- Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegenerationEnvironmental Toxicology and Pharmacology, 2005