Prostate cancer survival is dependent on season of diagnosis
- 1 September 2007
- journal article
- research article
- Published by Wiley in The Prostate
- Vol. 67 (12), 1362-1370
- https://doi.org/10.1002/pros.20577
Abstract
BACKGROUND We have earlier found that the prognosis for several cancers is dependent on season of diagnosis. More recently, both prostate cancer incidence and mortality have been shown to increase with increasing latitude, which probably relates to photosynthesis of vitamin D. METHODS The 3 year survival of prostate cancer patients has been analyzed with the Cox regression method for two age groups at different latitudes in Norway. RESULTS Patients diagnosed during the summer and autumn had the best prognosis (Ralative risk (RR) death 0.8; 95% CI 0.75–0.85). Similar results were observed in three regions of the country that differ with respect to annual fluences of solar UV radiation, incidence rates of squamous cell carcinoma (SCC) and intake of fish. Furthermore, similar relationship between the season and survival was seen among patients ≤65 years and >65 years old, although the younger group had a slightly larger advantage of summer and autumn diagnosis. CONCLUSIONS The seasonal effect on prognosis may be related to the seasonal variations of calcidiol (the marker of vitamin D status). The lack of latitude effect and the similarity of prognosis for different age groups may be related to higher consumption of vitamin D in food in the north region and to increase of such consumption with age. Prostate 67: 1362–1370, 2007.Keywords
This publication has 54 references indexed in Scilit:
- UV, latitude, and spatial trends in prostate cancer mortality: All sunlight is not the same (United States)Cancer Causes & Control, 2006
- Changes in risk of death from breast cancer with season and latitudeBreast Cancer Research and Treatment, 2006
- Cancer survival is dependent on season of diagnosis and sunlight exposureInternational Journal of Cancer, 2006
- Variation in Incidence and Fatality of Melanoma by Season of Diagnosis in New South Wales, AustraliaCancer Epidemiology, Biomarkers & Prevention, 2006
- Vitamin D3from sunlight may improve the prognosis of breast-, colon- and prostate cancer (Norway)Cancer Causes & Control, 2004
- A Multicountry Ecologic Study of Risk and Risk Reduction Factors for Prostate Cancer MortalityEuropean Urology, 2003
- Sunlight and mortality from breast, ovarian, colon, prostate, and non-melanoma skin cancer: a composite death certificate based case-control studyOccupational and Environmental Medicine, 2002
- Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trialThe Lancet, 1999
- Aging decreases the capacity of human skin to produce vitamin D3.JCI Insight, 1985
- Vitamin-D Synthesis and Metabolism after Ultraviolet Irradiation of Normal and Vitamin-D-Deficient SubjectsNew England Journal of Medicine, 1982