On the Mechanism Underlying (23S)-25-Dehydro-1α(OH)-vitamin D3-26,23-lactone Antagonism of hVDRwt Gene Activation and Its Switch to a Superagonist
Open Access
- 1 December 2009
- journal article
- Published by Elsevier BV
- Vol. 284 (52), 36292-36301
- https://doi.org/10.1074/jbc.m109.042069
Abstract
No abstract availableThis publication has 34 references indexed in Scilit:
- New insights into Vitamin D sterol-VDR proteolysis, allostery, structure–function from the perspective of a conformational ensemble modelThe Journal of Steroid Biochemistry and Molecular Biology, 2007
- Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1α,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysisThe Journal of Steroid Biochemistry and Molecular Biology, 2004
- Paget’s disease—A VDR coactivator disease?The Journal of Steroid Biochemistry and Molecular Biology, 2004
- Synthesis and structure–activity relationships of TEI-9647 derivatives as Vitamin D3 antagonistsThe Journal of Steroid Biochemistry and Molecular Biology, 2004
- Steroid-hormone rapid actions, membrane receptors and a conformational ensemble modelNature Reviews Drug Discovery, 2004
- Enhancement of VDR-Mediated Transcription by Phosphorylation: Correlation with Increased Interaction Between the VDR and DRIP205, a Subunit of the VDR-Interacting Protein Coactivator ComplexMolecular Endocrinology, 2002
- (23S)- and (23R)-25-dehydro-1α-hydroxyvitamin D3-26,23-lactone function as antagonists of vitamin D receptor-mediated genomic actions of 1α,25-dihydroxyvitamin D3Steroids, 2001
- Enhanced biological activity of 1α,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1α,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activityThe Journal of Steroid Biochemistry and Molecular Biology, 1999
- 1α,25‐Dihydroxyvitamin D3‐26,23‐lactone analogs antagonize differentiation of human leukemia cells (HL‐60 cells) but not of human acute promyelocytic leukemia cells (NB4 cells)FEBS Letters, 1999
- Antagonistic Action of Novel 1α,25-Dihydroxyvitamin D3-26,23-lactone Analogs on Differentiation of Human Leukemia Cells (HL-60) Induced by 1α,25-Dihydroxyvitamin D3Published by Elsevier BV ,1999