Benidipine improves oxidized LDL-dependent monocyte and endothelial dysfunction in hypertensive patients with type 2 diabetes mellitus
- 14 April 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Human Hypertension
- Vol. 19 (7), 551-557
- https://doi.org/10.1038/sj.jhh.1001863
Abstract
We investigated the effects of long-term benidipine treatment on levels of monocyte and endothelial cell activation markers in hypertensive patients with (n=28) and without (n=10) type 2 diabetes mellitus. Benidipine, 4 mg/day, was administered for 6 months; there were no other changes in any of the patients pharmacologic regimens during benidipine treatment. Clinical and biochemical data obtained before and after benidipine administration were compared; all markers were measured by ELISA. The levels of platelet activation markers (CD62P, CD63, and PAC-1), microparticles (monocyte-derived microparticles: MDMPs, and endothelial cell-derived microparticles: EDMPs), chemokines (monocyte chemotactic peptide 1: MCP-1, regulated on activation normally T-cell expressed and secreted: RANTES) and soluble adhesion markers (soluble E-selectin and soluble ICAM-1) differed in the control and hypertension groups. In addition, levels of platelet, monocyte, and endothelial cell activation markers, microparticles, chemokines, and soluble adhesion molecules were higher in hypertensive patients than in those without type 2 diabetes. Furthermore, benidipine administration decreased the concentrations of all these markers. The effect of this drug was significant in diabetes patients with high levels of antioxidized low-density lipoprotein (LDL) antibody. These results suggest that benidipine is effective for the treatment of oxLDL-dependent vascular disorders in hypertensive patients with type 2 diabetes.Keywords
This publication has 42 references indexed in Scilit:
- Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injuryKidney International, 2000
- 1,4-Dihydropyridine Calcium Channel Blockers Inhibit Plasma and LDL Oxidation and Formation of Oxidation-Specific Epitopes in the Arterial Wall and Prolong Survival in Stroke-Prone Spontaneously Hypertensive RatsStroke, 1999
- Flow cytometric analysis of platelet activation markers CD62P and CD63 in patients with coronary artery diseaseEuropean Journal of Clinical Investigation, 1996
- Benidipine Improves Endothelial Function in Renal Resistance Arteries of Hypertensive RatsHypertension, 1996
- National High Blood Pressure Education Program Working Group report on hypertension in diabetes.Hypertension, 1994
- Diabetes Mellitus and Macrovascular Complications: An epidemiological perspectiveDiabetes Care, 1992
- Long-term comparison between captopril and nifedipine in the progression of renal insufficiencyKidney International, 1992
- Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.The Journal of Experimental Medicine, 1992
- Functional tissue factor is entirely cell surface expressed on lipopolysaccharide-stimulated human blood monocytes and a constitutively tissue factor-producing neoplastic cell line.The Journal of cell biology, 1989
- The effects of nifedipine, a calcium antagonist, on platelet functionAmerican Heart Journal, 1983