Association of radiographic changes of osteoarthritis, symptoms, and synovial fluid particles in 300 knees.
Open Access
- 1 February 1993
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 52 (2), 97-103
- https://doi.org/10.1136/ard.52.2.97
Abstract
Associations between compartmental distribution of radiographic changes of osteoarthritis (OA), individual features of OA (joint space loss, sclerosis, cyst, osteophyte; each scored 0-3), and presence of synovial fluid calcium particles (calcium pyrophosphate dihydrate (CPPD) crystals identified by polarised light microscopy and other calcium particles by alizarin red positivity (ARP) were sought in 300 osteoarthritic knees (178 patients; mean age 72, range 33-96 years). Patients whose knees were symptom free as well as those with symptoms were included. Osteoarthritis of two or three compartments but not unicompartmental OA was associated with the presence of CPPD or ARP. Involvement of any compartment (not just patellofemoral), and higher mean scores for both total and individual osteoarthritis changes (except cysts) was associated with CPPD and ARP; CPPD, but not ARP, was associated with symptoms: knees reported as having symptoms had higher mean total OA scores. Femoral cortical erosion, found more often in women, was associated with higher mean total OA score at the patellofemoral compartment but not with the presence of particles. Attrition, remodelling, and chondrocalcinosis (each scored as present or absent) occurred more often in knees with CPPD. Age did not correlate with any aspect of the OA score. This study confirms the association of calcium particles with the process of OA. Unlike previous studies confined to symptomatic knees, a radiographic pattern specific to CPPD ('pyrophosphate arthropathy') did not emerge.Keywords
This publication has 26 references indexed in Scilit:
- INORGANIC PYROPHOSPHATE, NUCLEOSIDE TRIPHOSPHATE PYROPHOSPHATASE, AND CARTILAGE FRAGMENTS IN NORMAL HUMAN SYNOVIAL FLUIDRheumatology, 1991
- Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the knee.Annals Of The Rheumatic Diseases, 1986
- Polarised light microscopy: principles and practice for the rheumatologist.Annals Of The Rheumatic Diseases, 1983
- Mechanical factors and patellofemoral osteoarthrosis.Annals Of The Rheumatic Diseases, 1979
- Identification of hydroxyapatite crystals in synovial fluidArthritis & Rheumatism, 1979
- Mixed crystal deposition disease and osteoarthritis.BMJ, 1978
- APATITE DEPOSITION DISEASE: A New ArthropathyThe Lancet, 1976
- Factors affecting the solubility of calcium pyrophosphate dihydrate crystals.JCI Insight, 1975
- ON THE HISTORY AND MECHANISM OF ALIZARIN AND ALIZARIN RED S STAINS FOR CALCIUMJournal of Histochemistry & Cytochemistry, 1969
- CRYSTAL-INDUCED INFLAMMATION IN CANINE JOINTSThe Journal of Experimental Medicine, 1966