Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China
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Open Access
- 6 December 2017
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 37 (2), 363-369
- https://doi.org/10.1007/s10096-017-3144-z
Abstract
Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR). HCoV-positive patients were then tested for 11 other respiratory pathogens. 4.3% (489/11399) of patients were positive for HCoV, of which 3.0% were positive for OC43 (346/11399), 0.6% for 229E (65/11399), 0.5% for NL63 (60/11399), and 0.3% for HKU1 (38/11399). Patients aged 7–12 months had the highest prevalence of HCoV and OC43 when compared with other age groups (p < 0.001). The peak seasons of infection varied depending on the HCoV strain. Patients infected with a single strain of HCoV infection were less likely to present fever (≥ 38 °C) (p = 0.014) and more likely to present pulmonary rales (p = 0.043) than those co-infected with more than one HCoV strain or other respiratory pathogens. There were also significant differences in the prevalence of certain symptoms, including coughing (p = 0.032), pneumonia (p = 0.026), and abnormal pulmonary rales (p = 0.002) according to the strain of HCoV detected. This retrospective study of the prevalence of four HCoV strains and clinical signs among a large population of pediatric patients in a subtropical region of China provides further insight into the epidemiology and clinical features of HCoV.Keywords
Funding Information
- Guangzhou Science and Technology Program key projects (201508020252)
- Guangzhou Science and Technology Program key projects (201504010032)
- National Natural Science Foundation of China (31500143)
- The State Major Infectious Disease Research Program (2017ZX10103011-003)
This publication has 27 references indexed in Scilit:
- Coronavirus infections in hospitalized pediatric patients with acute respiratory tract diseaseBMC Infectious Diseases, 2012
- Diagnostic value of respiratory virus detection in symptomatic children using real-time PCRVirology Journal, 2012
- Characterization of Human Coronavirus Etiology in Chinese Adults with Acute Upper Respiratory Tract Infection by Real-Time RT-PCR AssaysPLOS ONE, 2012
- Detection of human bocavirus from children and adults with acute respiratory tract illness in Guangzhou, southern ChinaBMC Infectious Diseases, 2011
- Viral Etiology of Acute Febrile Respiratory Illnesses in Hospitalized Children Younger Than 24 MonthsClinical Pediatrics, 2011
- Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR MethodJournal of Clinical Microbiology, 2010
- Detection of four human coronaviruses in respiratory infections in children: A one‐year study in ColoradoJournal of Medical Virology, 2009
- Structure of the Main Protease from a Global Infectious Human Coronavirus, HCoV-HKU1Journal of Virology, 2008
- Coronavirus HKU1 and Other Coronavirus Infections in Hong KongJournal of Clinical Microbiology, 2006
- Coronavirus HKU1 Infection in the United StatesEmerging Infectious Diseases, 2006