The Gray Zone Between Burkitt's Lymphoma and Diffuse Large B-Cell Lymphoma From a Genetics Perspective
- 10 May 2011
- journal article
- review article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 29 (14), 1835-1843
- https://doi.org/10.1200/jco.2010.32.8385
Abstract
It has long been recognized that the border between classical Burkitt's lymphoma (BL) and classical diffuse large B-cell lymphoma (DLBCL) is hard to determine. Instead, both classical lymphoma entities seem to be the extreme ends of a spectrum of diseases that contains a group of lymphomas characterized predominately by the fact that they are hard to assign to the one or the other group. This gray zone has been recently termed “lymphoma, unclassifiable, with features intermediate between DLBCL and BL” by the updated WHO classification. The term “intermediate” resembles that from a recent gene-expression study of mature aggressive B-cell lymphomas, although, notably, it is used differently. Intermediate lymphomas according to the WHO classification clearly are a temporary container of different biologic subtypes of aggressive lymphoma, from which several might be associated with an unfavorable clinical outcome. The present review aims at describing the morphologic, clinical, and biologic heterogeneity of the intermediate lymphomas and, moreover, attempts to propose testable subgroups based on age and presence of genetic aberrations.Keywords
This publication has 44 references indexed in Scilit:
- Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHLBlood, 2010
- Detection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysisHaematologica, 2010
- Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international studyLeukemia, 2008
- Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledgeLeukemia, 2008
- Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphomaHaematologica, 2008
- Molecular profiling of pediatric mature B-cell lymphoma treated in population-based prospective clinical trialsBlood, 2008
- Molecular Diagnosis of Burkitt's LymphomaNew England Journal of Medicine, 2006
- A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic ProfilingNew England Journal of Medicine, 2006
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000
- Non-Hodgkin's lymphomas of childhood and adolescence: results of a treatment stratified for biologic subtypes and stage--a report of the Berlin-Frankfurt-Münster Group.Journal of Clinical Oncology, 1995