High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury
Open Access
- 1 January 2011
- journal article
- Published by Springer Science and Business Media LLC in Arthritis Research & Therapy
- Vol. 13 (6), R198
- https://doi.org/10.1186/ar3529
Abstract
Increasing obesity and type 2 diabetes, in part due to the high-fat (HF) Western diet, parallels an increased incidence of osteoarthritis (OA). This study was undertaken to establish a causal relation between the HF diet and accelerated OA progression in a mouse model and to determine the relative roles of weight gain and metabolic dysregulation in this progression.Keywords
This publication has 55 references indexed in Scilit:
- Establishment of an index with increased sensitivity for assessing murine arthritisJournal of Orthopaedic Research, 2011
- Oxidative stress and the etiology of insulin resistance and type 2 diabetesFree Radical Biology & Medicine, 2010
- Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalencePopulation Health Metrics, 2010
- Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammationProstaglandins, Leukotrienes & Essential Fatty Acids, 2009
- Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritisArthritis & Rheumatism, 2009
- Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort studyAnnals Of The Rheumatic Diseases, 2009
- Induction of an osteoarthritis‐like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic miceArthritis & Rheumatism, 2008
- Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam StudyAnnals Of The Rheumatic Diseases, 2007
- Obesity induces a phenotypic switch in adipose tissue macrophage polarizationJCI Insight, 2007
- Global and societal implications of the diabetes epidemicNature, 2001