Physical Activity, Occupational Sitting Time, and Colorectal Cancer Risk in the Netherlands Cohort Study
Open Access
- 17 February 2013
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Epidemiology
- Vol. 177 (6), 514-530
- https://doi.org/10.1093/aje/kws280
Abstract
We investigated occupational energy expenditure and sitting time in the longest held job (in men only), nonoccupational physical activity, and former sports participation in relation to colorectal cancer endpoints. The Netherlands Cohort Study includes 120,852 participants who completed a self-administered questionnaire in 1986 when they were aged 55–69 years. By 2002, 1,819 male and 1,366 female colorectal cancer cases were available for case-cohort analyses. In men, higher occupational energy expenditure levels and fewer occupational sitting hours were associated with decreased hazard ratios for colon cancer, particularly distal colon cancer (occupational energy expenditure of ≥12 vs. P for trend = 0.01; occupational sitting hours of 90 vs. ≤30 minutes/day, HR = 0.69, 95% CI: 0.50, 0.96; P for trend = 0.06), and rectal cancer (>90 vs. ≤30 minutes/day, HR = 0.59, 95% CI: 0.39, 0.90; P for trend = 0.02). In conclusion, regular long-term physical activity and fewer sitting hours may protect against colon cancer, particularly distal colon cancer; results for rectal cancer were mixed.Keywords
This publication has 33 references indexed in Scilit:
- Height and cancer incidence in the Million Women Study: prospective cohort, and meta-analysis of prospective studies of height and total cancer riskThe Lancet Oncology, 2011
- Change in Physical Activity and Colon Cancer Incidence and MortalityCancer Epidemiology, Biomarkers & Prevention, 2010
- State of the epidemiological evidence on physical activity and cancer preventionEuropean Journal of Cancer, 2010
- Childhood and adolescent energy restriction and subsequent colorectal cancer risk: results from the Netherlands Cohort StudyInternational Journal of Epidemiology, 2010
- Early Life Exposure to Famine and Colorectal Cancer Risk: A Role for Epigenetic MechanismsPLOS ONE, 2009
- Self-reported Clothing Size as a Proxy Measure for Body SizeEpidemiology, 2009
- Physical activity and colon cancer prevention: a meta-analysisBritish Journal of Cancer, 2009
- No Reduction in C-Reactive Protein following a 12-Month Randomized Controlled Trial of Exercise in Men and WomenCancer Epidemiology, Biomarkers & Prevention, 2008
- Compendium of Physical Activities: classification of energy costs of human physical activitiesMedicine & Science in Sports & Exercise, 1993
- Partial residuals for the proportional hazards regression modelBiometrika, 1982