Vitiligo Treatment with Monochromatic Excimer Light and Tacrolimus: Results of an Open Randomized Controlled Study
- 1 January 2012
- journal article
- research article
- Published by Mary Ann Liebert Inc in Photomedicine and Laser Surgery
- Vol. 30 (1), 26-30
- https://doi.org/10.1089/pho.2011.3029
Abstract
Background data: Narrow band ultraviolet B (UVB) is an effective and safe option for the treatment of vitiligo. However, a complete and long-lasting repigmention of vitiligo patches is difficult to achieve. Combined treatments with novel sources of phototherapy and topical agents represent possible new strategies. Objective: The purpose of this study was to compare the efficacy of combined tacrolimus and 308-nm excimer light (MEL) vs 308-nm MEL monotherapy in treating vitiligo in a controlled study. Methods: Fifty-three patients affected by vitiligo were enrolled in this open prospective study. Patients were divided into three groups: Group I included 20 patients treated with MEL 308 nm twice weekly and oral vitamin E; Group II included 20 patients treated with MEL 308 nm twice weekly combined with 0.1% tacrolimus once a day and oral vitamin E; and Group III included 13 patients treated only with oral vitamin E. Efficacy was assessed at the end of 12 weeks based on the percentage of repigmentation. Results: Fifty-two patients completed 12 weeks of treatment. Group I (MEL + vitamin E) showed a moderate repigmentation in 35% of patients, good repigmentation in 30%, excellent repigmentation in 25%, and poor repigmentation in 10%; Group II (MEL + tacrolimus 0.1%+ vitamin E) presented moderate repigmentation in 25% of patients, good repigmentation in 40%, excellent repigmentation in 30%, and poor repigmentation in 5%; Group III (vitamin E) showed moderate repigmentation in 16% and 84% did not show signs of repigmentation. Conclusions: Our results demonstrate that the combination treatment of 0.1% tacrolimus ointment plus 308-nm MEL and 308-nm MEL monotherapy are effective, safe, and well tolerated for the treatment of vitiligo compared to treatment with vitamin E. Furthermore, this study suggests that an association with topical immunomodulators could enhance the clinical response in vitiligo, especially in more resistant anatomical sites.Keywords
This publication has 17 references indexed in Scilit:
- Clinical efficacy of a 308 nm excimer laser in the treatment of vitiligoPhotodermatology, Photoimmunology & Photomedicine, 2010
- 308-nm excimer lamp vs. 308-nm excimer laser for treating vitiligo: a randomized studyBritish Journal of Dermatology, 2010
- Monochromatic excimer light 308 nm in monotherapy and combined with topical khellin 4% in the treatment of vitiligo: a controlled studyDermatologic Therapy, 2009
- Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trialClinical and Experimental Dermatology, 2007
- Narrow‐band UVB phototherapy combined with tacrolimus ointment in vitiligo: a review of 110 patientsJournal of the European Academy of Dermatology and Venereology, 2007
- Calcineurin Inhibitors Decrease DNA Repair and Apoptosis in Human Keratinocytes Following Ultraviolet B IrradiationJournal of Investigative Dermatology, 2005
- Topical Calcineurin Inhibitors Decrease the Production of UVB-Induced Thymine Dimers from Hairless Mouse EpidermisDermatology, 2005
- Study Design and Preliminary Results from the Pilot Phase of the PraKtis Study: Self-Reported Diagnoses of Selected Skin Diseases in a Representative Sample of the Italian PopulationDermatology, 2004
- Repigmentation of chronic vitiligo lesions by following tacrolimus plus ultraviolet‐B–narrow‐bandPhotodermatology, Photoimmunology & Photomedicine, 2003
- Treatment of vitiligoJournal of Dermatological Treatment, 2002