Androgen Receptor Signaling in Salivary Gland Cancer
Open Access
- 7 February 2017
- Vol. 9 (2), 17
- https://doi.org/10.3390/cancers9020017
Abstract
Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer.This publication has 68 references indexed in Scilit:
- FOXA1 mutations in hormone-dependent cancersFrontiers in Oncology, 2013
- FOXA1: master of steroid receptor function in cancerThe EMBO Journal, 2011
- Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptorProceedings of the National Academy of Sciences of the United States of America, 2010
- Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variantJCI Insight, 2010
- Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary glandPathology, 2009
- Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs)Oral Oncology, 2009
- A Novel Androgen Receptor Splice Variant Is Up-regulated during Prostate Cancer Progression and Promotes Androgen Depletion–Resistant GrowthCancer Research, 2009
- Splicing of a Novel Androgen Receptor Exon Generates a Constitutively Active Androgen Receptor that Mediates Prostate Cancer Therapy ResistanceCancer Research, 2008
- Partial remission of parotid gland carcinoma after goserelinThe Lancet, 1994
- Malignant salivary gland tumorsInternational Journal of Radiation Oncology*Biology*Physics, 1986