Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L
- 6 February 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 359 (1), 78-80
- https://doi.org/10.1016/0014-5793(94)01456-b
Abstract
A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a Ki of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.This publication has 13 references indexed in Scilit:
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