The bodies fight against cancer: is human leucocyte antigen (HLA) class 1 the key?
- 18 March 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Krebsforschung und Klinische Onkologie
- Vol. 138 (5), 723-728
- https://doi.org/10.1007/s00432-012-1192-4
Abstract
Loss of human leucocyte antigen (HLA) class I expression has been implicated in tumour progression and metastasis; however, studies reporting its relationship with long-term survival are few in number with conflicting reports. The aim of this review was to assess the prognostic value of HLA class I expression in gastrointestinal cancer. Major electronic databases, including Medline, Embase, Cochrane Library and Pubmed were searched for original studies. Two independent reviewers assessed each study against inclusion and exclusion criteria. All data were specific to gastrointestinal cancer surgery. Fourteen original studies were included in this present review. In oesophageal cancer, reduced expression of HLA-A, HLA-B, HLA-C and HLA-G were associated with poorer survival. However, in gastric and colorectal cancer, the prognostic value of HLA-A, HLA-B, HLA-C and HLA-G remains conflicting. Antibody use and reporting methodology was different between all 14 studies examined. Variability in antibody use makes it difficult to validate HLA class I expression as an independent prognostic marker in GI cancer. Consensus guidelines, incorporating heavy and light chain antibodies, are required with further studies on HLA class I expression being performed to validate its prognostic value.Keywords
This publication has 39 references indexed in Scilit:
- Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancerEuropean Journal of Cancer, 2009
- Downregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinomaBritish Journal of Cancer, 2008
- Clinical significance of HLA class I heavy chain expression in patients with gastric cancerJournal of Surgical Oncology, 2008
- Clinical impact of HLA class I expression in rectal cancerCancer Immunology, Immunotherapy, 2007
- Expression of Human Leukocyte Antigen G (HLA-G) Correlates with Poor Prognosis in Gastric CarcinomaAnnals of Surgical Oncology, 2007
- Human leukocyte antigen G expression: as a significant prognostic indicator for patients with colorectal cancerLaboratory Investigation, 2007
- Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical OutcomeScience, 2006
- Inflammation and prognosis in colorectal cancerEuropean Journal of Cancer, 2005
- Inflammation and necrosis promote tumour growthNature Reviews Immunology, 2004
- Frequency of abnormal expression of HLA-A,B,C and HLA-DR molecules, invariant chain, and LFA-3 (CD58) in colorectal carcinoma and its impact on tumor recurrenceInternational Journal of Cancer, 1991