Risk factors for multicentric occurrence of carcinoma in the upper aerodigestive tract—analysis with a serial histologic evaluation of the whole resected‐esophagus including carcinoma
- 21 July 2003
- journal article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 83 (4), 216-221
- https://doi.org/10.1002/jso.10276
Abstract
Background and Objectives We have reported that both lifestyle and family history might be related to multiplicity of carcinoma in the upper aerodigestive tract (UADT). The aim of this study was to elucidate the relationship between the number of carcinomas and risk factors. Methods A serial histologic evaluation of the entire non‐irradiated esophagus was performed in 114 males with esophageal cancer who were divided into three groups (group I: 88 cases with solitary cancer, group II: 11 with double cancers, group III: 15 with three or more cancers). As controls, 228 males with benign diseases were selected. Results Among group III patients, both the incidence of heavy smoking and that of heavy drinking were 67% and 60%, which were significantly higher than those of group I (28% and 30%) and control subjects (14% and 10%, respectively). Heavy drinkers who were also heavy smokers were observed in 2, 10, 27, and 47% in control subjects, groups I, II, and III, respectively. Regarding family history, 27% of group III had a close relative with UADT or lung cancer, while the incidence was 7% in the control. Conclusions These findings strongly support the hypothesis that heavy smoking and heavy drinking, as well as a family history of both UADT and lung cancer, might be risk factors for multicentric occurrence of UADT cancer. J. Surg. Oncol. 2003;83:216–221.Keywords
This publication has 16 references indexed in Scilit:
- Multiple Head and Neck Tumors Frequently Originate from a Single Preneoplastic LesionThe American Journal of Pathology, 2002
- Risk factors for esophageal cancer and the multiple occurrence of carcinoma in the upper aerodigestive tractSurgery, 2002
- Family aggregation of carcinoma of the hypopharynx and cervical esophagus: Special reference to multiplicity of cancer in upper aerodigestive tractInternational Journal of Cancer, 1998
- The multicentric occurrence of squamous epithelial dysplasia and squamous cell carcinoma in the esophagusCancer, 1994
- Multiple occurrence of carcinoma in the upper aerodigestive tract associated with esophageal cancer: Reference to smoking, drinking and family historyInternational Journal of Cancer, 1994
- Histopathologic findings of minute foci of squamous cell carcinoma in the human esophagusCancer, 1991
- Serial histologic evaluation of multiple primary squamous cell carcinomas of the esophagusCancer, 1988
- Familial history of esophageal cancerCancer, 1985
- Multiple primary malignant tumors of the head and neckAmerican Journal of Otolaryngology, 1980
- Simultaneous Carcinomas of the Esophagus and Upper Aerodigestive TractOtolaryngology -- Head and Neck Surgery, 1980