Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature

Abstract

Endosomes do not traffic autonomously but instead associate with the ER membrane. ER tubules wrap around and maintain contact with both early and late endosomes by ER ring rearrangements. As endosomes mature, they increase the degree of their ER association, which suggests that the ER might play a role in endosomal maturation.