Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins
- 1 March 1984
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 308 (5955), 153-158
- https://doi.org/10.1038/308153a0
Abstract
Comparison of the sequence of a cloned T cell-specific c[complementary]DNA with those of cross-reacting cloned cDNA isolated from a [murine] thymocyte library indicates the presence of variable, constant and joining regions remarkably similar in size and sequence to those encoding Ig proteins. Together with the evidence for somatic gene rearrangements reported previously, this strongly suggests that the TM86 cDNA clone encodes 1 chain of the T-cell antigen receptor.Keywords
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