New approaches to combat Porphyromonas gingivalis biofilms
Open Access
- 1 January 2017
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Oral Microbiology
- Vol. 9 (1), 1300366
- https://doi.org/10.1080/20002297.2017.1300366
Abstract
In nature, bacteria predominantly reside in structured, surface-attached communities embedded in a self-produced, extracellular matrix. These so-called biofilms play an important role in the development and pathogenesis of many infections, as they are difficult to eradicate due to their resistance to antimicrobials and host defense mechanisms. This review focusses on the biofilm-forming periodontal bacterium Porphyromonas gingivalis. Current knowledge on the virulence mechanisms underlying P. gingivalis biofilm formation is presented. In addition, oral infectious diseases in which P. gingivalis plays a key role are described, and an overview of conventional and new therapies for combating P. gingivalis biofilms is given. More insight into this intriguing pathogen might direct the development of better strategies to combat oral infections.Keywords
Funding Information
- Industrial Research Fund of KU Leuven (IOF/KP/11/007)
- Research Foundation – Flanders FWO (G.0413.10)
- European Commission’s Seventh Framework Program (COATIM (project no. 278425))
- Research Foundation – Flanders FWO (G0B2515N)
- Interuniversity Attraction Poles Program initiated by the Belgian Science Policy Office (P7/28)
- Research Foundation – Flanders FWO (G.0471.12N)
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