Perilesional treatment of metastatic melanoma with interferon-β
- 2 September 2009
- journal article
- Published by Oxford University Press (OUP) in Clinical and Experimental Dermatology
- Vol. 34 (7), 793-799
- https://doi.org/10.1111/j.1365-2230.2009.03207.x
Abstract
Previous trials with various treatments have not shown satisfactory therapeutic results for cutaneous metastasis of malignant melanoma (MM). We report three patients who were treated with peritumoral injection of interferon (IFN)‐β for multiple skin metastases of MM. The metastatic tumours were infiltrated by significant numbers of CD8+ TIA+ cytotoxic lymphocytes, and the numbers of CD4+ cells and human leucocyte antigen‐DR+ cells increased after IFN‐β injection. These results suggest that the peritumoral administration of IFN‐β enhanced the antitumour immune response against the MM, suggesting that it is a promising supportive treatment for skin metastasis of MM.Keywords
This publication has 15 references indexed in Scilit:
- Single-agent interleukin-2 in the treatment of metastatic melanoma: A systematic reviewCancer Treatment Reviews, 2007
- lnterferon‐β gene therapy for cancer: Basic research to clinical applicationCancer Science, 2004
- Treatment of locoregional metastases of malignant melanomas with radiotherapy and intralesional ??-interferon injectionMelanoma Research, 2003
- Direct Evidence That IFN-β Functions as a Tumor-Suppressor ProteinJournal of Interferon & Cytokine Research, 2002
- Growth inhibition of human malignant melanoma transfected with the human interferon-β gene by means of cationic liposomesMelanoma Research, 2001
- New Guidelines to Evaluate the Response to Treatment in Solid TumorsJNCI Journal of the National Cancer Institute, 2000
- High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993Journal of Clinical Oncology, 1999
- Long term response to chemotherapy in patients with visceral metastatic melanomaAnnals of Oncology, 1994
- Growth regulation of melanoma cells by interferon and (2'-5')oligoadenylate synthetase.Molecular and Cellular Biology, 1983
- Intralesional Immunotherapy of Melanoma with BCGMedical Clinics of North America, 1976