Topically Applied Botulinum Toxin Type A for the Treatment of Primary Axillary Hyperhidrosis
- 1 January 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Dermatologic Surgery
- Vol. 33 (s1), S76-S80
- https://doi.org/10.1111/j.1524-4725.2006.32335.x
Abstract
The objective was to demonstrate that botulinum toxin type A (BTX-A) can be delivered to targeted skin sites with topical application for the treatment of primary axillary hyperhidrosis. This randomized, blinded, vehicle-controlled study enrolled 12 patients with primary axillary hyperhidrosis with greater than 50 mg of sweat produced per 5 minutes. BTX-A (200 U), combined with a proprietary transport peptide molecule to bind the toxin in a noncovalent manner, was topically applied to one axilla; vehicle without BTX-A was applied to the other axilla. Rates of sweat production were measured and imaged at baseline and 4 weeks after application. Two patients were excluded from analyses. At 4 weeks, 10 axillae treated topically with BTX-A demonstrated a 65.3+/-21.5% mean reduction in sweating relative to the same-patient, vehicle-control axillae, which had a 25.3+/-66.2% mean reduction. The 40% difference in mean sweat reduction between groups was statistically significant (p<.05). Quantitative image analysis of the results of the Minor's iodine starch test confirmed the reduction of sweat production in the BTX-A-treated versus the vehicle-treated axillae. Topically applied BTX-A appears to be safe and may prove to be effective for the treatment of axillary hyperhidrosis.Keywords
This publication has 7 references indexed in Scilit:
- The place of botulinum toxin type A in the treatment of focal hyperhidrosisBritish Journal of Dermatology, 2004
- Results of thoracoscopic sympathectomy for the treatment of axillary and palmar hyperhidrosis with respect to compensatory hyperhidrosis and dry handsSurgical Endoscopy, 2004
- US prevalence of hyperhidrosis and impact on individuals with axillary hyperhidrosis: Results from a national surveyJournal of the American Academy of Dermatology, 2004
- Botulinum Toxin A for Axillary Hyperhidrosis (Excessive Sweating)New England Journal of Medicine, 2001
- Side-controlled intradermal injection of botulinum toxin A in recalcitrant axillary hyperhidrosisJournal of the American Academy of Dermatology, 1999
- Focal HyperhidrosisArchives of Dermatology, 1998
- Ein neues Verfahren zu der klinischen Untersuchung der SchweißabsonderungZeitschrift für Neurologie, 1928