Dissecting the Role of Curcumin in Tumour Growth and Angiogenesis in Mouse Model of Human Breast Cancer
Open Access
- 1 January 2015
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2015, 1-7
- https://doi.org/10.1155/2015/878134
Abstract
Breast cancer is considered the most common cancer for women worldwide and it is now the second leading cause of cancer-related deaths among females in the world. Since breast cancer is highly resistant to chemotherapy, alternative anticancer strategies have been developed. In particular, many studies have demonstrated that curcumin, a derivative of turmeric, can be used as natural agent in treatment of some types of cancer by playing antiproliferative and antioxidant effects. In our study, we assessed the antitumor activities of curcumin in ER-negative human breast cancer cell line resistant to chemotherapy, MDA.MB231 byin vitroandin vivoexperiments.In vitrodata allowed us to demonstrate that curcumin played a role in regulation of proliferation and apoptosis in MDA.MB231 cells.In vivo, by generation of mouse model of breast cancer, we showed that treatment of curcumin inhibited tumor growth and angiogenesis. Specifically, we showed that curcumin is able to deregulate the expression of cyclin D1, PECAM-1, and p65, which are regulated by NF-κB. Our data demonstrated that curcumin could be used as an adjuvant agent to chemotherapy in treatment of triple negative breast cancer.Keywords
Funding Information
- Institute National of Tumors, IRCCS “Foundation G. Pascale”, Naples (Italy)
This publication has 36 references indexed in Scilit:
- The Effect of Curcumin on Breast Cancer CellsJournal of Breast Cancer, 2013
- Effects of curcumin on global gene expression profiles in the highly invasive human breast carcinoma cell line MDA‑MB 231: A gene network-based microarray analysisExperimental and Therapeutic Medicine, 2012
- The role of estrogen receptor alpha in mediating chemoresistance in breast cancer cellsJournal of Experimental & Clinical Cancer Research, 2012
- Pure curcumin decreases the expression of WT1 by upregulation of miR-15a and miR-16-1 in leukemic cellsJournal of Experimental & Clinical Cancer Research, 2012
- Platinum resistance in breast and ovarian cancer cell linesJournal of Experimental & Clinical Cancer Research, 2011
- The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: AnIn VitroandIn VivoComparison Study with HerceptinEvidence-Based Complementary and Alternative Medicine, 2011
- Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-κBp65 expression in breast cancer MDA-MB-231 cellsInternational Journal of Molecular Medicine, 2009
- Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteinsCancer Letters, 2008
- Curcumin suppresses breast tumor angiogenesis by abrogating osteopontin-induced VEGF expressionMolecular Medicine Reports, 2008
- J. E. Harkness und J. E. Wagner: The Biology and Medicine of Rabbits and Rodents. 152 Seiten. Lea and Febinger, Philadelphia 1977. Preis: 8,‐ $Molecular Nutrition & Food Research, 1979