Phytochemical Properties and Anti-Proliferative Activity of Olea europaea L. Leaf Extracts against Pancreatic Cancer Cells
Open Access
- 16 July 2015
- Vol. 20 (7), 12992-13004
- https://doi.org/10.3390/molecules200712992
Abstract
Olea europaea L. leaves are an agricultural waste product with a high concentration of phenolic compounds; especially oleuropein. Oleuropein has been shown to exhibit anti-proliferative activity against a number of cancer types. However, they have not been tested against pancreatic cancer, the fifth leading cause of cancer related death in Western countries. Therefore, water, 50% ethanol and 50% methanol extracts of Corregiola and Frantoio variety Olea europaea L. leaves were investigated for their total phenolic compounds, total flavonoids and oleuropein content, antioxidant capacity and anti-proliferative activity against MiaPaCa-2 pancreatic cancer cells. The extracts only had slight differences in their phytochemical properties, and at 100 and 200 μg/mL, all decreased the viability of the pancreatic cancer cells relative to controls. At 50 μg/mL, the water extract from the Corregiola leaves exhibited the highest anti-proliferative activity with the effect possibly due to early eluting HPLC peaks. For this reason, olive leaf extracts warrant further investigation into their potential anti-pancreatic cancer benefits.This publication has 28 references indexed in Scilit:
- Oleuropein and hydroxytyrosol activate GPER/ GPR30‐dependent pathways leading to apoptosis of ER‐negative SKBR3 breast cancer cellsMolecular Nutrition & Food Research, 2013
- Protective role of oleuropein and its metabolite hydroxytyrosol on cancerTrends in Food Science & Technology, 2013
- Oleuropein, a Secoiridoid Derived from Olive Tree, Inhibits the Proliferation of Human Colorectal Cancer Cell Through Downregulation of HIF-1αNutrition and Cancer, 2013
- Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin™) in HER2-overexpressing breast cancer cellsBMC Cancer, 2007
- Olive oil and the cardiovascular systemPharmacological Research, 2007
- Signalling networks regulating cyclooxygenase-2The International Journal of Biochemistry & Cell Biology, 2006
- Proteomic Classification of Pancreatic Adenocarcinoma Tissue Using Protein Chip TechnologyGastroenterology, 2006
- Oleuropein, a non-toxic olive iridoid, is an anti-tumor agent and cytoskeleton disruptorBiochemical and Biophysical Research Communications, 2005
- Targeting the mitogen-activated protein kinase cascade to treat cancerNature Reviews Cancer, 2004
- On the In-vitro Antimicrobial Activity of Oleuropein and HydroxytyrosolJournal of Pharmacy and Pharmacology, 1999