The orthoandmetaMagnesiation of Functionalized Anilines and Amino-Substituted Pyridines and Pyrazines at Room Temperature
- 20 September 2012
- journal article
- research article
- Published by Wiley in Angewandte Chemie
- Vol. 51 (42), 10624-10627
- https://doi.org/10.1002/anie.201205465
Abstract
A practical ortho,meta, (or even ortho,ortho') magnesiation of trifluoroacetamides of anilines, aminopyridines, and aminopyrazines at room temperature was performed with TMPMgCl⋅LiCl or TMP(2) Mg⋅2 LiCl. These magnesiations are compatible with several carbonyl functionalities and allow access to polysubstituted anilides in satisfactory yields.This publication has 53 references indexed in Scilit:
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