Recent Advances in the Discovery and Development of Marine Microbial Natural Products
Open Access
- 7 March 2013
- journal article
- review article
- Published by MDPI AG in Marine Drugs
- Vol. 11 (3), 700-717
- https://doi.org/10.3390/md11030700
Abstract
Marine microbial natural products (MMNPs) have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists during the last few decades. Numerous studies have indicated that diverse marine microbes appear to have the capacity to produce an impressive array of MMNPs exhibiting a wide variety of biological activities such as antimicrobial, anti-tumor, anti-inflammatory and anti-cardiovascular agents. Marine microorganisms represent an underexplored reservoir for the discovery of MMNPs with unique scaffolds and for exploitation in the pharmaceutical and agricultural industries. This review focuses on MMNPs discovery and development over the past decades, including innovative isolation and culture methods, strategies for discovering novel MMNPs via routine screenings, metagenomics, genomics, combinatorial biosynthesis, and synthetic biology. The potential problems and future directions for exploring MMNPs are also discussed.Keywords
This publication has 101 references indexed in Scilit:
- The expanding role of marine microbes in pharmaceutical developmentCurrent Opinion in Biotechnology, 2010
- Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small moleculesCurrent Opinion in Microbiology, 2010
- Fluostatins Produced by the Heterologous Expression of a TAR Reassembled Environmental DNA Derived Type II PKS Gene ClusterJournal of the American Chemical Society, 2010
- Siderophores from Neighboring Organisms Promote the Growth of Uncultured BacteriaCell Chemical Biology, 2010
- Natural Products from Environmental DNA Hosted in Ralstonia metalliduransACS Chemical Biology, 2009
- Arenamides A−C, Cytotoxic NFκB Inhibitors from the Marine Actinomycete Salinispora arenicolaJournal of Natural Products, 2008
- Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome InhibitorsJournal of the American Chemical Society, 2008
- Natural Products as Sources of New Drugs over the Last 25 YearsJournal of Natural Products, 2007
- Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus SalinosporaAngewandte Chemie-International Edition, 2003
- Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)Nature, 2002