Mr perfusion studies with t1‐weighted echo planar imaging
- 1 December 1995
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 34 (6), 878-887
- https://doi.org/10.1002/mrm.1910340613
Abstract
The T1 perfusion model has worked well in brain functional studies where flow changes are measured. Using selective and nonselective inversion pulses, a new method has been developed to study steady‐state brain blood flow. The authors obtained flow‐sensitive images using selective inversion and flow‐insensitive images using nonselective inversion. Subtraction of flow‐insensitive images from flow‐sensitive images gave us flow‐weighted images with good gray‐white flow contrast in cortical gray matter as well as in the thalamus and basal ganglia. Fitting T1S of flow‐insensitive and flow‐sensitive images allowed us to obtain preliminary results of brain blood flow maps. Two specific problems can seriously affect the accuracy of the brain blood flow values and the gray‐white flow contrast of brain blood flow maps. These are the problems of the partial volume effect of CSF and gray matter, and the difference between blood T1 and white matter T1. The authors discuss in detail the character of these problems and present a number of approaches to manage such problems.Keywords
This publication has 6 references indexed in Scilit:
- Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency.Radiology, 1994
- Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Perfusion imagingMagnetic Resonance in Medicine, 1992
- MR angiography by selective inversion recoveryMagnetic Resonance in Medicine, 1987
- Mechanisms of Contrast in NMR ImagingJournal of Computer Assisted Tomography, 1984
- Blood-brain barrier permeability of 11C-labeled alcohols and 15O-labeled waterAmerican Journal of Physiology-Legacy Content, 1976