Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo
Open Access
- 24 June 1991
- journal article
- Published by Wiley in FEBS Letters
- Vol. 284 (2), 263-266
- https://doi.org/10.1016/0014-5793(91)80699-4
Abstract
A series of dioleoyl N‐(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG‐PE) of different polymer chain length was used in this study. Both the activity of PEG‐PE in prolonging the circulation time of liposomes and the relative steric barrier activity of amphipathic polymer, measured by a liposome agglutination assay, were found to be directly proportional to the chain length of PEG‐PE (PEG5000‐PE > PEG2000‐PE > PEG750‐PE). However, PEG5000‐PE caused a reduced target binding of immunoliposomes in mice due to its overly strong steric barrier activity. The best PEG‐PE species supporting the target binding of immunoliposomes was PEG2000‐PE, the activity of which was compatible to that of ganglioside GM1. However, GM1 only showed a weak steric barrier activity, suggesting a different mechanism for this glycolipid.Keywords
This publication has 17 references indexed in Scilit:
- Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: Studies with poly(ethylene glycol)-coated vesiclesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1991
- Liposomes for the sustained drug release in vivoBiochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomesFEBS Letters, 1990
- pH-sensitive, plasma-stable liposomes with relatively prolonged residence in circulationBiochimica et Biophysica Acta (BBA) - Biomembranes, 1990
- Differential properties of organ-specific serum opsonins for liver and spleen macrophagesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- Liposomes with prolonged circulation times: factors affecting uptake by reticuloendothelial and other tissuesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1989
- Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.Proceedings of the National Academy of Sciences of the United States of America, 1988
- Large unilamellar liposomes with low uptake into the reticuloendothelial systemFEBS Letters, 1987
- A new hydrophobic anchor for the attachment of proteins to liposomal membranesFEBS Letters, 1986
- On the mode of liposome-cell interactions. Biotin-conjugated lipids as ultrastructural probesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1979