Cytotoxic Isoflavans from Eysenhardtia polystachya
- 1 June 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 61 (6), 767-770
- https://doi.org/10.1021/np970586b
Abstract
Two new cytotoxic isoflavans, (3S)-7-hydroxy-2',3',4',5', 8-pentamethoxyisoflavan (1) and (3S)-3',7-dihydroxy-2',4',5', 8-tetramethoxyisoflavan (2), were isolated from the bark and trunks of Eysenhardtia polystachya (Leguminosae), together with the known constituents stigmasterol, isoduartin, cuneatin, 7-hydroxy-2',4', 5'-trimethoxyisoflavone, and 3,4-dimethoxy-8, 9-(methylenedioxy)pterocarpan. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods. The antimicrobial, cytotoxic, and insecticidal potential of some of these compounds were evaluated. The isoflavans 1, 2, and isoduartin (2', 7-dihydroxy-3',4',8-trimethoxyisoflavan) displayed moderate cytotoxic activity against KB cell lines.Keywords
This publication has 5 references indexed in Scilit:
- Coluteol and Colutequinone B, More Antifungal Isoflavonoids from Colutea arborescensJournal of Natural Products, 1998
- Colutequinone and colutehydroquinone, antifungal isoflavonoids from Colutea arborescensPhytochemistry, 1996
- Bioactive Polyacetylenes fromBidens pilosaPlanta Medica, 1996
- Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera.CHEMICAL & PHARMACEUTICAL BULLETIN, 1985
- An isoflavone and a coumestan from eysenhardtia polystachya—Robert Boyle's fluorescent acid—base indicatorPhytochemistry, 1984