An approach to acanthosis nigricans
Open Access
- 1 January 2014
- journal article
- review article
- Published by Medknow in Indian Dermatology Online Journal
- Vol. 5 (3), 239-49
- https://doi.org/10.4103/2229-5178.137765
Abstract
Acanthosis nigricans (AN) is characterized by dark, coarse and thickened skin with a velvety texture, being symmetrically distributed on the neck, the axillae, antecubital and popliteal fossae, and groin folds, histopathologically characterized by papillomatosis and hyperkeratosis of the skin. A high prevalence of AN has been observed recently. Different varieties of AN include benign, obesity associated, syndromic, malignant, acral, unilateral, medication-induced and mixed AN. Diagnosis is largely clinical with histopathology needed only for confirmation. Other investigations needed are fasting lipoprotein profile, fasting glucose, fasting insulin, hemoglobin and alanine aminotransferase for obesity associated AN and radiological investigations (plain radiography, ultrasonography, magnetic resonance imaging/computerized tomography) for malignancy associated AN. The most common treatment modalities include retinoids and metforminKeywords
This publication has 34 references indexed in Scilit:
- Acanthosis nigricans--An uncommon cutaneous adverse effect of a common medication: Report of two casesIndian Journal of Dermatology, Venereology and Leprology, 2013
- Occult Cause of Paraneoplastic Acanthosis Nigricans in a Patient with Known Breast Dcis: Case and ReviewCurrent Oncology, 2012
- Atypical presentation of acanthosis nigricansIndian Journal of Endocrinology and Metabolism, 2012
- Skin tags and acanthosis nigricans in patients with hepatitis C infection in relation to insulin resistance and insulin like growth factor-1 levelsIndian Journal of Dermatology, 2012
- Abnormal Glucose Metabolism in Hispanic Parents of Children with Acanthosis NigricansISRN Endocrinology, 2011
- Critical comparison of diffuse reflectance spectroscopy and colorimetry as dermatological diagnostic tools for acanthosis nigricans: a chemometric approachBiomedical Optics Express, 2011
- Unilateral Nevoid Acanthosis Nigricans with a Submammary LocationAnnals of Dermatology, 2011
- A study of pathogenesis of Acanthosis nigricans and its clinical implicationsIndian Journal of Dermatology, 2011
- Surrogate markers of insulin resistance: A reviewWorld Journal of Diabetes, 2010
- Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndromeJCI Insight, 2006