Clot waveform analysis using CS‐2000i™ distinguishes between very low and absent levels of factor VIII activity in patients with severe haemophilia A
- 27 July 2017
- journal article
- Published by Wiley in Haemophilia
- Vol. 23 (5), e427-e435
- https://doi.org/10.1111/hae.13266
Abstract
A recently developed method to assess comprehensive coagulation function, clot waveform analysis (CWA), accurately detect low levels (P<.05). A new parameter (slope-|min1|) reflecting average coagulation acceleration was derived. This index (median) was lower in HA-inh (0.0042) compared to ES-HA (0.0068) and VS-HA (0.011) with greater significant differences (P<.01), and an index of <.005 reflected the total absence of FVIII in the presence of inhibitor. The slope-|min1| parameter could provide a useful index for evaluating very low and absent levels of FVIII and/or the development of FVIII inhibitor in HA-pts.Keywords
Funding Information
- Scientific Research (Kakenhi)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) (15K09663)
This publication has 20 references indexed in Scilit:
- Laboratory Diagnosis of Acquired Hemophilia A: Limitations, Consequences, and ChallengesSeminars in Thrombosis and Hemostasis, 2014
- Optimal monitoring of bypass therapy in hemophilia A patients with inhibitors by the use of clot waveform analysisJournal of Thrombosis and Haemostasis, 2014
- Towards standardization of clot waveform analysis and recommendations for its clinical applicationsJournal of Thrombosis and Haemostasis, 2013
- Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2)Journal of Thrombosis and Haemostasis, 2012
- Prevalence, biological phenotype and genotype in moderate/mild hemophilia A with discrepancy between one‐stage and chromogenic factor VIII activityJournal of Thrombosis and Haemostasis, 2010
- New assays for monitoring haemophilia treatmentHaemophilia, 2008
- The Phenotypic Heterogeneity of Severe HemophiliaSeminars in Thrombosis and Hemostasis, 2008
- Phenotypic heterogeneity in severe hemophiliaJournal of Thrombosis and Haemostasis, 2007
- The measurement of low levels of factor VIII or factor IX in hemophilia A and hemophilia B plasma by clot waveform analysis and thrombin generation assayJournal of Thrombosis and Haemostasis, 2006
- A longitudinal study of orthopaedic outcomes for severe factor‐VIII‐deficient haemophiliacsJournal of Internal Medicine, 1994