Adverse effects of beta-blockade withdrawal in patients with congestive cardiomyopathy.
- 1 August 1980
- Vol. 44 (2), 134-142
- https://doi.org/10.1136/hrt.44.2.134
Abstract
Fifteen patients with congestive cardiomyopathy who had improved conspicuously on chronic administration of a beta-blocker were studied after withdrawal of the drug. In six patients there was a pronounced deterioration of their clinical condition, and in all of the remaining patients there was a significant decrease in ejection fraction, and signs of compromised diastolic function with pathological apex curves and an increase in third heart sound. All these changes were reversed within a few weeks to a few months after readministration of beta-blocking drugs. This study supports the idea that an aetiological factor in congestive cardiomyopathy may be a pathological response to sympathetic stimulation which could be partly controlled by administration of beta-blocking drugs.Keywords
This publication has 10 references indexed in Scilit:
- Beneficial effects of long-term beta-blockade in congestive cardiomyopathy.Heart, 1980
- Haemodynamic effects of a new beta 1-receptor agonist in acute myocardial infarction. A useful antidote to unwanted cardiac effects of beta-blocking agents.Heart, 1979
- Mechanism of propranolol withdrawal phenomena.Circulation, 1979
- PROLONGATION OF SURVIVAL IN CONGESTIVE CARDIOMYOPATHY BY BETA-RECEPTOR BLOCKADEThe Lancet, 1979
- Hemodynamic and metabolic response after abrupt uithdrawal of long-term propranolol.Circulation, 1978
- Haemodynamic and tolerance studies in man of a new, orally active, selective? 1-adrenoceptor agonist H 80/62European Journal of Clinical Pharmacology, 1978
- In vitro effects of catecholamines on protein synthesis in perfused rat heart*1Journal of Molecular and Cellular Cardiology, 1976
- Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.Heart, 1975
- Propranolol-Withdrawal Rebound PhenomenonThe New England Journal of Medicine, 1975
- Catecholamine excretion and cardiac stores of norepinephrine in congestive heart failureThe American Journal of Medicine, 1965