Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors
- 1 July 2003
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in Pediatric Critical Care Medicine
- Vol. 4 (3), 377-381
- https://doi.org/10.1097/01.pcc.0000074274.58997.fe
Abstract
During the Australian summer of 2000/2001, there was an outbreak of enterovirus 71 infection in Sydney. Between December 2000 and May 2001, approximately 200 children presented to Sydney Children's Hospital with hand-foot-and-mouth disease and 18 experienced neurologic complications. Four presented with acute invasive central nervous system disease and severe pulmonary edema. We describe the cardiorespiratory disturbances and intensive care management of these four consecutive children successfully treated for neurogenic pulmonary edema attributed to proven enterovirus 71 infection. All four survived the acute stage of the illness. However, all four have been left with significant debilitating morbidity. Epidemic enterovirus 71 brainstem encephalitis presenting as neurogenic pulmonary edema can be successfully managed in the pediatric intensive care unit but has great potential to yield a large number of handicapped toddlers and become "the poliomyelitis of the 21st century."Keywords
This publication has 32 references indexed in Scilit:
- Enterovirus 71 — Emerging Infections and Emerging QuestionsThe New England Journal of Medicine, 1999
- An Epidemic of Enterovirus 71 Infection in TaiwanThe New England Journal of Medicine, 1999
- Haemodynamic changes in neurogenic pulmonary oedema: Effect of dobutamineIntensive Care Medicine, 1996
- Medullary lesion inducing pulmonary edema: A magnetic resonance imaging studyAnnals of Neurology, 1991
- Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvementThe Pediatric Infectious Disease Journal, 1988
- Nucleus tractus solitarius lesions elevate pulmonary arterial pressure and lymph flowAnnals of Neurology, 1985
- Chlorpromazine treatment for neurogenic pulmonary edemaCritical Care Medicine, 1985
- Electrocardiographic changes in cerebrovascular hemorrhageAmerican Heart Journal, 1980
- Neurogenic pulmonary edema in childhoodThe Journal of Pediatrics, 1979
- Respiratory Insufficiency in Combat CasualitiesAnnals of Surgery, 1969