Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria
Top Cited Papers
Open Access
- 13 November 2019
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 69 (Supplement), S521-S528
- https://doi.org/10.1093/cid/ciz824
Abstract
Carbapenem resistance in gram-negative bacteria has caused a global epidemic that continues to grow. Although carbapenemase-producing Enterobacteriaceae have received the most attention because resistance was first reported in these pathogens in the early 1990s, there is increased awareness of the impact of carbapenem-resistant nonfermenting gram-negative bacteria, such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. Moreover, evaluating the problem of carbapenem resistance requires the consideration of both carbapenemase-producing bacteria as well as bacteria with other carbapenem resistance mechanisms. Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbapenem-resistant organisms can help us gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.Keywords
Funding Information
- Shionogi & Co, Ltd
This publication has 64 references indexed in Scilit:
- Correlation between penicillin-binding protein 2 mutations and carbapenem resistance in Escherichia coliJournal of Medical Microbiology, 2013
- Strategies for identification of carbapenemase-producing EnterobacteriaceaeJournal of Antimicrobial Chemotherapy, 2012
- Rapid Detection of Carbapenemase-producingEnterobacteriaceaeEmerging Infectious Diseases, 2012
- Pan-β-Lactam Resistance Development in Pseudomonas aeruginosa Clinical Strains: Molecular Mechanisms, Penicillin-Binding Protein Profiles, and Binding AffinitiesAntimicrobial Agents and Chemotherapy, 2012
- Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II studyInternational Journal of Antimicrobial Agents, 2012
- Analysis of Genes Encoding Penicillin-Binding Proteins in Clinical Isolates of Acinetobacter baumanniiAntimicrobial Agents and Chemotherapy, 2011
- Global Spread of Carbapenemase-producingEnterobacteriaceaeEmerging Infectious Diseases, 2011
- Updated Functional Classification of β-LactamasesAntimicrobial Agents and Chemotherapy, 2010
- Molecular Epidemiology and Mechanisms of Carbapenem Resistance in Pseudomonas aeruginosaAntimicrobial Agents and Chemotherapy, 2009
- Interplay of Efflux System, ampC , and oprD Expression in Carbapenem Resistance of Pseudomonas aeruginosa Clinical IsolatesAntimicrobial Agents and Chemotherapy, 2006