Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters Measured with Cirrus HD-OCT in Glaucomatous Eyes
Top Cited Papers
- 1 November 2010
- journal article
- glaucoma
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 51 (11), 5724-5730
- https://doi.org/10.1167/iovs.10-5222
Abstract
Purpose.: To assess the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters measured with Cirrus HD-OCT in glaucomatous eyes. Methods.: Fifty-five glaucomatous eyes were included in the study. The optic disc cube 200 × 200 protocol was used to obtain three scans during the same visit to evaluate the intravisit reproducibility. One scan on 4 additional days within a 2-month period of the first session was obtained to assess intervisit reproducibility. Intraclass correlation coefficient (ICC), coefficient of variation (CV), and test-retest SD (TRT SD) were calculated for each RNFL and ONH parameter. The formula 1.645 × √2 × intervisit TRT SD provides an upper tolerance limit to variability beyond which nonphysiologic change should be considered. Results.: All ICCs were excellent, ranging from 83.9% to 99.2% for intravisit measurements and from 80.8% to 99.1% for intervisit measurements. Cup/disc area ratio had the lowest CV (1.1%) in either type of measurement, followed by average RNFL thickness (1.9% and 2.7%). Nasal clock hours and quadrants showed the poorest reproducibility as did the clock hour directly temporally. The intervisit tolerance limit for average RNFL thickness was 3.89 μm. Conclusions.: Intravisit and intervisit measurements of peripapillary RNFL thickness and ONH parameters with Cirrus HD-OCT showed excellent reproducibility, indicating that this instrument may be useful in monitoring glaucoma progression. When comparing two measurements from the same eye on two different visits, a reproducible decrease in average RNFL thickness of approximately 4 μm or more may be considered a statistically significant change from baseline.Keywords
This publication has 20 references indexed in Scilit:
- Reproducibility of RTVue Retinal Nerve Fiber Layer Thickness and Optic Disc Measurements and Agreement with Stratus Optical Coherence Tomography MeasurementsAmerican Journal of Ophthalmology, 2009
- Artifacts on the Optic Nerve Head Analysis of the Optical Coherence Tomography in Glaucomatous and Nonglaucomatous EyesJournal of Glaucoma, 2009
- Longitudinal Evaluation of Optic Disc Measurement Variability With Optical Coherence Tomography and Confocal Scanning Laser OphthalmoscopyJournal of Glaucoma, 2009
- Reproducibility of Retinal Thickness Measurements in Healthy Subjects Using Spectralis Optical Coherence TomographyAmerican Journal of Ophthalmology, 2008
- Longitudinal Variability of Optic Disc and Retinal Nerve Fiber Layer MeasurementsInvestigative Opthalmology & Visual Science, 2008
- Reproducibility of Peripapillary Retinal Nerve Fiber Thickness Measurements with Stratus OCT in Glaucomatous EyesOphthalmology, 2008
- Optical Coherence Tomography of the Optic Nerve HeadJournal of Glaucoma, 2006
- Reproducibilidad del estudio de la cabeza del nervio óptico y de la capa de fibras nerviosas mediante tomografía óptica de coherenciaArchivos de la Sociedad Española de Oftalmología, 2006
- Reproducibility of Optic Nerve Head Measurements Obtained by Optical Coherence TomographyEuropean Journal of Ophthalmology, 2005
- Analysis of Retinal Nerve Fiber Layer and Optic Nerve Head in Glaucoma with Different Reference Plane Offsets, Using Optical Coherence TomographyPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2005