Safety of repeated transplantations of neurotrophic factors‐secreting human mesenchymal stromal stem cells

Abstract

Therapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies. We have shown that, using a medium-based approach, MSC can be induced to secrete elevated levels of neurotropic factors, which have been shown to have protective effects in animal models of neurodegenerative diseases.