Mutagenic and Toxic Activity of some Jordanian Medicinal Plants
- 1 January 1995
- journal article
- research article
- Published by Informa UK Limited in International Journal of Pharmacognosy
- Vol. 33 (1), 61-64
- https://doi.org/10.3109/13880209509088149
Abstract
A total of 39 ethanol extracts of Jordanian plants were examined for cytotoxicity and mutagenicity. Among the tested plants, 8 extracts were active in the brine shrimp cytotoxicity bioassay with LC50 values in the range of 2.5-870 μg/ml. These positive extracts were further tested for their antitumor activity on human tumor cell lines in culture. Eminium spiculatum showed activity against a lung carcinoma line (A-549) with an ED50 of 0.0793 μg/ ml. Regarding mutagenic effect, 16 of the extracts were active on Salmonella typhim-urium strains TA98 or TA 102, and the extract of Podonosma oriantalis showed mutagenic activity in both strains.Keywords
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