γδβ-Thalassaemias 1 and 2 are the result of a 100 kbp deletion in the human β-globin cluster
Open Access
- 11 September 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (17), 7017-7029
- https://doi.org/10.1093/nar/14.17.7017
Abstract
The DNA spanning two large deletions in the human β-globin gene cluster (γβ-thalassaemia 1 and 2) has been cloned by cosmid cloning and chromosomal walking. The entire region was mapped and analyzed for the presence of repetitive sequences. The results show that the affected loci have lost almost 100kb of DNA in a deletion event not involving homologous or repetitive sequences.Keywords
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