Analysis of Biomolecules Based on the Surface Enhanced Raman Spectroscopy
Open Access
- 15 September 2018
- journal article
- review article
- Published by MDPI AG in Nanomaterials
- Vol. 8 (9), 730
- https://doi.org/10.3390/nano8090730
Abstract
Analyzing biomolecules is essential for disease diagnostics, food safety inspection, environmental monitoring and pharmaceutical development. Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for detecting biomolecules due to its high sensitivity, rapidness and specificity in identifying molecular structures. This review focuses on the SERS analysis of biomolecules originated from humans, animals, plants and microorganisms, combined with nanomaterials as SERS substrates and nanotags. Recent advances in SERS detection of target molecules were summarized with different detection strategies including label-free and label-mediated types. This comprehensive and critical summary of SERS analysis of biomolecules might help researchers from different scientific backgrounds spark new ideas and proposals.Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada (NSERCRGPIN-2014-05487)
This publication has 174 references indexed in Scilit:
- Molecular characterization of hepcidin gene in common carp (Cyprinus carpio L.) and its expression pattern responding to bacterial challengeFish & Shellfish Immunology, 2013
- Monitoring the Chemical Production of Citrus-Derived Bioactive 5-Demethylnobiletin Using Surface-Enhanced Raman SpectroscopyJournal of Agricultural and Food Chemistry, 2013
- Induced Expression of AtLEC1 and AtLEC2 Differentially Promotes Somatic Embryogenesis in Transgenic Tobacco PlantsPLOS ONE, 2013
- In Situ Strain-Level Detection and Identification of Vibrio parahaemolyticus Using Surface-Enhanced Raman SpectroscopyAnalytical Chemistry, 2013
- A versatile SERS-based immunoassay for immunoglobulin detection using antigen-coated gold nanoparticles and malachite green-conjugated protein A/GBiosensors and Bioelectronics, 2010
- SERS detection of biomolecules using lithographed nanoparticles towards a reproducible SERS biosensorNanotechnology, 2010
- Surface-enhanced Raman spectroscopy in living plant using triplex Au-Ag-C core-shell nanoparticlesJournal of Raman Spectroscopy, 2010
- Surface-enhanced Raman spectroscopy of DNA from leaves of in vitro grown apple plantsJournal of Raman Spectroscopy, 2010
- SERS detection of indirect viral DNA capture using colloidal gold and methylene blue as a Raman labelBiosensors and Bioelectronics, 2009
- Understanding SERS of bacteriaJournal of Raman Spectroscopy, 2008