HEPATIC ANGIOSARCOMA ASSOCIATED WITH ANDROGENIC-ANABOLIC STEROIDS
- 1 November 1979
- journal article
- research article
- Published by Elsevier BV in The Lancet
- Vol. 314 (8152), 1120-1123
- https://doi.org/10.1016/s0140-6736(79)92515-7
Abstract
A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964-74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, `Thorotrast', and inorganic arsenic) and 4 (3·1%) of the remaining 131 cases with the use of androgenic-anabolic steroids. It is suggested that the long-term use of androgenic-anabolic steroids is the fourth cause of HAS, the majority of cases still being of unknown ætiology. Moreover, the presented cases serve as a link in a spectrum of hepatic disorders recently recognised to be caused by environmental agents such as vinyl chloride, arsenic, and thorotrast, and by contraceptive and anabolic steroids. Similar precursor stages, usually not recognised by clinical laboratory tests and consisting of areas of hyperplasia of hepatocytes and sinusoidal cells and sinusoidal dilatation, lead potentially to hepatic adenoma, carcinoma, peliosis, and angiosarcoma.This publication has 18 references indexed in Scilit:
- Angiosarcoma of the liver associated with diethylstilbestrolJAMA, 1978
- HEPATOCELLULAR CARCINOMA IN YOUNG WOMEN ON ORAL CONTRACEPTIVESThe Lancet, 1978
- THE CLINICAL, RADIOLOGIC, AND PATHOLOGIC CHARACTERIZATION OF BENIGN HEPATIC NEOPLASMSMedicine, 1978
- LIVER DAMAGE FROM LONG-TERM METHYLTESTOSTERONEThe Lancet, 1977
- Hyperplasia and prolapse of hepatocytes into hepatic veins during longterm methyltestosteronetherapy: possible relationships of these changes to the development of peliosis hepatis and liver tumoursHistopathology, 1977
- Hepatic adenomas and oral contraceptives.Gut, 1975
- Peliosis Hepatis Associated with Androgenic-Anabolic Steroid TherapyAnnals of Internal Medicine, 1974
- Hepatic disease among workers at a vinyl chloride polymerization plantPublished by American Medical Association (AMA) ,1974
- POSSIBLE ASSOCIATION BETWEEN BENIGN HEPATOMAS AND ORAL CONTRACEPTIVESThe Lancet, 1973
- ASSOCIATION OF ANDROGENIC-ANABOLIC STEROID THERAPY WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMAThe Lancet, 1972