A novel and essential role for FcγRIIa in cancer cell–induced platelet activation
- 9 January 2014
- journal article
- Published by American Society of Hematology in Blood
- Vol. 123 (2), 249-260
- https://doi.org/10.1182/blood-2013-03-492447
Abstract
Key Points: The immune receptor FcγRIIa is a key mediator of tumor cell activation of platelets in the circulation. Secretion of adenosine 5′-diphosphate from dense granules is the primary response of platelets to activation by tumor cells.Keywords
This publication has 46 references indexed in Scilit:
- Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes MetastasisCancer Cell, 2011
- Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesisBlood, 2011
- Normal ranges of angiogenesis regulatory proteins in human plateletsAmerican Journal of Hematology, 2010
- Comparison of Tumor and Microenvironment Secretomes in Plasma and in Platelets during Prostate Cancer Growth in a Xenograft ModelNeoplasia, 2010
- Platelet-Derived Transforming Growth Factor-β Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor ReactivityCancer Research, 2009
- Selective sorting of alpha-granule proteinsJournal of Thrombosis and Haemostasis, 2009
- Platelet Granule Secretion Continuously Prevents Intratumor HemorrhageCancer Research, 2008
- Exhausted platelets in patients with malignant solid tumors without evidence of active consumption coagulopathyEuropean Journal of Cancer and Clinical Oncology, 1984
- Antimetastatic effects associated with platelet reduction.Proceedings of the National Academy of Sciences of the United States of America, 1968
- Thrombocytosis Associated With Malignant DiseaseArchives of Internal Medicine, 1964